alexa Rodent Models of Painful Diabetic Neuropathy: What Can We Learn from Them? | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Review Article

Rodent Models of Painful Diabetic Neuropathy: What Can We Learn from Them?

Anne-Sophie Wattiez1,2#, David André Barrière1,2*#, Amandine Dupuis1,2 and Christine Courteix1,2

1Clermont Université, Université d’Auvergne, Pharmacologie Fondamentale et Clinique de la Douleur, France

2Inserm, U 1107, Neuro-Dol, F-63001 Clermont-Ferrand, France

#Equal Contribution

*Corresponding Author:
David André Barrière
Clermont Université
Université d’Auvergne
Pharmacologie Fondamentale et Clinique de la Douleur
BP 10448, F-63000 Clermont-Ferrand, France
Tel: 0033473 278 230
Fax: 0033473 274621
E-mail: [email protected]

Received date: April 02, 2012; Accepted date: May 26, 2012; Published date: May 29, 2012

Citation: Wattiez AS, Barrière DA, Dupuis A, Courteix C (2012) Rodent Models of Painful Diabetic Neuropathy: What Can We Learn from Them? J Diabetes Metab S5:008.doi:10.4172/2155-6156.S5-008

Copyright: © 2012 Wattiez AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Abstract

Diabetic peripheral neuropathy (DPN) is the most common clinical complication of diabetes mellitus, and can be related to type 1 as well as type 2. To date, this highly invalidating neurological impairment is insufficiently known, understood and the treatments proposed by physicians are still empirical and poorly efficient. Animal rodent modeling of clinical DPN offers a powerful tool in order to understand diabetes-mediated peripheral nerve injury. The majority of studies which have investigated DPN in rodent used the streptozotocin-induced rat model which reproduces metabolic lesional mechanisms of Type 1 Diabetes Mellitus (T1DM) and usual symptoms of evoked pain. Although the clinical relevance of this model is challenged due to 1) a high prevalence of type 2- compared to type 1-diabetes in the adult population, 2) the important alteration of the general clinical state of the animals and 3) the lack of morphological changes in peripheral nerves, many studies have contributed to a better pathophysiological and pharmacological understanding of the DPN. In this review we investigated rodent models of T1DM and T2DM, their contributions for a better understanding of DPN, molecular targets and pharmacological strategies, which could be used for the enhancement of clinical care. Finally, we proposed possible ways to improve animal modeling.

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