alexa Role of 17β-Estradiol in Learning and Memory | OMICS International | Abstract
ISSN: 2167-0420

Journal of Womens Health Care
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Review Article

Role of 17β-Estradiol in Learning and Memory

Paola Rossi1* and Valentina Cesaroni2

1Department of Biology and Biotechnology, L Spallanzani, University of Pavia, Italy

2Laboratory of Neurobiology and Physiology integrated, University of Pavia, Italy

Corresponding Author:
Paola Rossi
Associate Professor, Department of Biology and Biotechnology
University of Pavia, Via Ferrata 9
Italia Pavia-27100, Italy
Tel: 39-0-382986835
E-mail: [email protected]

Received Date: October 20, 2015; Accepted Date: October 22, 2015; Published Date: October 30, 2015

Citation: Rossi P, Cesaroni V (2015) Role of 17ß-Estradiol in Learning and Memory. J Women’s Health Care 4:282. doi:10.4172/2167-0420.1000282

Copyright: © 2015 Rossi P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract

Ovarian hormones regulate a wide variety of non-reproductive functions in the central nervous system by interacting with several molecular and cellular processes. Estrogens are steroid hormones that are synthesized in the gonads [peripherally-synthesized or “neuroactive steroids”] as well as in various tissues throughout the body, including the brain [brain-synthetized or “neurosteroids”]. 17β-Estradiol [E2] is the most potent and predominant form of estrogen. E2 has a number of effects on cognition and brain function. The effects on memory depend on hormone levels and on binding to different estrogen receptors within neural circuits.
The purpose of this review is to highlight the complex relationship between E2 and cognitive functioning, analyzing the difference of effects described by observational studies compared to randomized controlled large-scale clinical trials. We review how E2 signaling affects memory processes: it starts from neurons and reaches superior learning and memory function through the effect on synapses and on the neuronal network.

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