Role of Aldosterone in Insulin Resistance: Fact of FantasyLeonardo A. Sechi*, GianLuca Colussi and Cristiana Catena
Department of Experimental and Clinical Medical Sciences, Hypertension Unit, Internal Medicine, University of Udine, Udine, Italy
- *corresponding Author:
- Leonardo A. Sechi
MD, Clinica Medica, University of Udine
University Hospital, Building 8
first floor, 33100 Udine, Italy
Tel: 39 0432 559804
Fax: 39 0432 559094
E-mail: [email protected]
Received Date: February 8, 2015, Accepted Date: February 19, 2015, Published Date: February 27, 2015
Citation: Sechi LA, Colussi GL, Catena C (2015) Role of Aldosterone in Insulin Resistance: Fact of Fantasy. Endocrinol Metab Synd 4:161. doi:10.4172/2161-1017.1000161
Copyright: © 2015 Sechi LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Recent evidence suggests that aldosterone decreases insulin sensitivity independent of its effects on blood pressure. This article discusses the evidence linking aldosterone to insulin resistance.
Objective: The role of aldosterone in causing alterations in insulin sensitivity might be relevant in patients with inappropriately elevated circulating levels of the hormone. Aldosterone and insulin resistance might together contribute to blood pressure raise and, eventually, increased cardiovascular risk.
Discussion: Evidence obtained in studies of patients with primary aldosteronism suggests that inappropriately elevated plasma aldosterone levels contribute to insulin resistance. However, the relative contribution of circulating aldosterone levels or hypertensive state itself to insulin resistance is not entirely clear.
Summary: Aldosterone antagonists might be beneficial in conditions associated with insulin resistance, but more research is needed to test this hypothesis.