alexa Role of Antioxidants in the Antidiabetic Potential of Two Indigenous Lebanese Inula Species
ISSN: 2167-0412

Medicinal & Aromatic Plants
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Special Issue Article

Role of Antioxidants in the Antidiabetic Potential of Two Indigenous Lebanese Inula Species

Assi M*, Ela MA, Raafat K and El-Lakany A
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, Lebanon
Corresponding Author : Assi M
Department of Pharmaceutical Sciences
Faculty of Pharmacy, Beirut Arab
University, 115020 Beirut, Lebanon
E-mail: [email protected]
Received May 26, 2015; Accepted June 22, 2015; Published June 26, 2015
Citation: Assi M, Ela MA, Raafat K, El-Lakany A (2015) Role of Antioxidants in the Antidiabetic Potential of Two Indigenous Lebanese Inula Species. Med Aromat Plants S2:002. doi:10.4172/2167-0412.S2-002
Copyright: © 2015 Assi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Inula species grown in Lebanon are known to have beneficial effects in improving human health. Several Inula species are used in traditional medicine as expectorants, antitussives, diaphoretics, antiemetics, and bactericides. In this study, different extracts of two Lebanese Inula species [Asteraceae], Inula viscosa [I. viscosa] and Inula vulgaris [I. vulgaris] aerial parts, were investigated for their in vivo and in vitro antioxidant and antidiabetic potential. Since increased oxidative stress has been linked to a shortening of life span, the antioxidant effect was studied due to the increased rate of oxidative damage during diabetes. Antioxidant activities of various extracts of the plant parts were measured using in vitro quenching of diphenyl-2-picrylhydrazyl free radical [DPPH radical scavenging assay] and in vivo assessment of catalase level in serum of alloxan-induced diabetic mice [6 groups, 3 mice/group]. The effect of various Inula spp. under investigation was studied for their acute [6 h] and subacute [8 days] potential on blood sugar level in alloxan-induced diabetic mice. I. viscosa and I. vulgaris have shown very promising antidiabetic and antioxidant effects, especially in vivo. Different extracts have demonstrated some variations in their antioxidant activities, due to difference in their total phenolic contents. It is highly important to consider Inula species in management of chronic diseases like, diabetes.

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