alexa Role of Autologous Bone Marrow Mononuclear Cells in Chronic Cervical Spinal Cord Injury-A Longterm Follow Up Study | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Role of Autologous Bone Marrow Mononuclear Cells in Chronic Cervical Spinal Cord Injury-A Longterm Follow Up Study

Alok Sharma1, Hemangi Sane2, Nandini Gokulchandran1, Pooja Kulkarni2* , Nancy Thomas3, Pradnya Bhovad3, Hema Biju3, Joji Joseph3 and Prerna Badhe1
1Department of Medical Services and Clinical research, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, India
2Department of Research & Development, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research Centre, India
3Department of Neuro Rehabilitation, NeuroGen Brain and Spine Institute, Surana Sethia Hospital and Research centre, India
Corresponding Author : Pooja Kulkarnico
NeuroGen Brain and Spine Institute
Surana Sethia Hospital and Research Centre
Suman Nagar, Sion- Trombay Road
Chembur, Mumbai-400071, India
Tel: +9122-25281610/+9122-25283706
E-mail: [email protected]
Received September 22, 2013; Accepted October 28, 2013; Published November 04, 2013
Citation: Sharma A, Sane H, Gokulchandran N, Kulkarni P, Thomas N, et al. (2013) Role of Autologous Bone Marrow Mononuclear Cells in Chronic Cervical Spinal Cord Injury-A Longterm Follow Up Study. J Neurol Disord 1:138. doi: 10.4172/2329-6895.1000138
Copyright: © 2013 Sharma A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Spinal cord injury often results into severe neurological deficits. Currently, there is no treatment available which can reverse the damage. Cell transplantation is a novel treatment strategy which has shown promising results in animal models of spinal cord injury. We administered fifty six chronic cervical spinal cord injury patients with autologous bone marrow mononuclear cells, intrathecally. As a part of the protocol, all the patients also underwent rehabilitation along with cell transplantation. On a mean follow up of 2 years ± 1 month, symptoms such as trunk stability, sitting balance, trunk muscle strength, upper limb strength, standing balance, deep touch sensation, bladder sensation, spasticity and walking balance demonstrated improvements. On performing McNemars test, a significant association was found between the improvements in these symptoms and the intervention. The improvement in Functional Independence Measure (FIM) scores was statistically significant using Wilcoxon Signed Rank test. A detailed analysis of factors such as age, cause of injury, chronicity of injury and rehabilitation before the intervention was performed. Here, we also compare this chronic cervical SCI group with chronic thoracolumbar SCI patients of our previous study. Though functional improvements were observed at greater extent in chronic thoracolumbar SCI group, the results in chronic cervical SCI group were also significant. Cell transplantation may promote neurofunctional recovery and improve the quality of life of the patients with chronic cervical spinal cord injury.

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