Role of CD10 Immunoshistochemical Expression in Discriminating the Categories of Phylloides TumorMuhammad Usman Tariq*, Saroona Haroon and Naila Kayani
Department of Pathology and Microbiology, Aga Khan University Hospital Karachi, Pakistan
- *Corresponding Author:
- Muhammad Usman Tariq
Section of Histopathology
Department of Pathology and Microbiology
Aga Khan University Hospital
Stadium Road, Karachi, 74800, Pakistan
Fax: +922134934294, +922134932095
E-mail: [email protected]
Received date: November 02, 2014; Accepted date: December 08, 2014; Published date: December 10, 2014
Citation: Tariq MU, Haroon S, Kayani N. (2014) Role of CD10 Immunoshistochemical Expression in Discriminating the Categories of Phylloides Tumor. J Cytol Histol 6:292. doi: 10.4172/2157-7099.1000292
Copyright: © 2014 Tariq MU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and objectives: Phylloides tumors are categorized as benign, borderline and malignant on the basis of histological features which are subjected to significant inter-observer variability. Our aim was to study the role of immunohistochemical expression of CD10 in discriminating benign, borderline and malignant categories of phylloides tumor.
Methods: The expression of CD10 was studied in 85 phylloides tumors (27 benign, 25 borderline, and 33 malignant) using immunohistochemistry to see whether the expression differed between these histologic categories. Chi-square test was applied to determine the significance of difference in CD10 expression among tumor categories. Significance was established at p<0.05.
Results: 5/27 (18.5%) benign, 16/25 (64%) borderline and 26/33 (78.8%) malignant cases expressed significant (2+ or 3+) staining. This expression of CD10 significantly varied among histological categories (p<0.001). Histological features such as stromal atypia, stromal cellularity, tumor margins, mitotic activity and tumor size correlated significantly with tumor categories as well as with CD10 expression.
Conclusion: From these highly significant results, we believe that there is a strong correlation between CD10 expression and tumor grade and it can be used as an adjunct diagnostic tool for categorizing Phylloides tumors along with other histological features.