alexa Role of Cell Wall Polysaccharides during Recognition of
ISSN: 2168-958X

Journal of Glycobiology
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Review Article

Role of Cell Wall Polysaccharides during Recognition of Candida albicans by the Innate Immune System

Luis A Perez-Garcia, Diana F Diaz-Jimenez, Adolfo Lopez-Esparza and Hector M Mora-Montes*
Department of Biology, Division of Natural Sciences, Campus Guanajuato, University of Guanajuato, Noria Alta s / n, col. Noria Alta, C.P. 36050, Guanajuato, Gto., Mexico
*Corresponding Author : Hector M Mora-Montes
Department of Biology, Division of Natural Sciences
Campus Guanajuato, University of Guanajuato, Noria Alta s/n
col. Noria Alta, C.P. 36050, Guanajuato, Mexico
Tel: +52-473-7320006
Fax: +52- 473-7320006
E-mail: [email protected]
Received December 13, 2011; Accepted January 02, 2012; Published January 02, 2012
Citation: Perez-Garcia LA, Diaz-Jimenez DF, Lopez-Esparza A, Mora-Montes HM (2011) Role of Cell Wall Polysaccharides during Recognition of Candida albicans by the Innate Immune System. J Glycobiology 1:102. doi: 10.4172/2168-958X.1000102
Copyright: © 2011 Perez-Garcia LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 
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Abstract

Candida albicans is a dimorphic, opportunistic fungal pathogen responsible for most of the systemic candidiasis reported worldwide. The cell wall is the outermost component of this pathogen, which protects the cell from sudden changes in the external environment, is in close contact with host tissues and cells, and is elaborated by polysaccharides that are not synthesized by human cells. Thus, it is not surprising that the wall is the main source of pathogen-associated molecular patterns that are recognized by immune cells, and recognition of such components is critical for the establishment of a protective anti-Candida response. Here we summarize the current information related to the C. albicans innate immune sensing, underlying the importance of cell wall polysaccharides for the recognition of this pathogen.

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