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Role of Chemokines and Chemokine Receptors in Prostate Cancer Development and Progression | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Review Article

Role of Chemokines and Chemokine Receptors in Prostate Cancer Development and Progression

Rajendra K. Singh1,2*, Akulapalli Sudhakar3,4,5 and Bal L. Lokeshwar1,2

1Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA

2Veterans Administration Miami Hospital, Miami, Florida, USA

3Cell Signaling and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, USA

4Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68131, USA

5Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA

*Corresponding Author:
Dr. Rajendra K Singh,
Department of Urology, Miller School of Medicine,
University of Miami, Miami,
FL 33136 USA,
Tel: (305) 243-1017,
Fax: (305) 243-9724,
E-mail: [email protected]

Received Date: May 11, 2010; Accepted Date: June 02, 2010; Published Date: July 02, 2010

Citation: Singh RK, Sudhakar A, Lokeshwar BL (2010) Role of Chemokines and Chemokine Receptors in Prostate Cancer Development and Progression. J Cancer Sci Ther 2:089-094. doi:10.4172/1948-5956.1000030

Copyright: © 2010 Singh RK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Prostate cancer (PC) is the second leading cause of cancer deaths in men in America and Western Europe. Epidemiological studies suggest that prostate cancer incidence increased in last few years in Asian population. The causes or consequences of increasing trend of prostate cancer incidence are not completely known. Emerging evidences suggest that among the many risk factors, inflammation is the major risk factor for developing prostate cancer and its progression to metastasis. It is proposed that exposure to environmental factors such as infectious agents, dietary agents and saturated lipids leads to injury of the prostate due to chronic inflammation and regenerative risk factor lesions referred to as proliferative inflammatory atrophy (PIA). These phenomena predominantly control by a number of proinflammatory macro molecules such as chemokines, and their receptors. Some recent studies suggest that many of these pro-inflammatory chemokines and their receptors are the products of protooncogenes or tumor suppressor pathways in many cancers including that of the prostate. This review article will focus on the current biology of chemokines and chemokine receptors pathways in genesis of prostate cancer. An understanding of this axis may enable researchers to develop targeted strategies for prostate cancer.

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