alexa Role of Clinical Pharmacist to Reduce Risk in Patients Involving Antiretroviral Drugs at Abidjan Cohort | OMICS International | Abstract
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Journal of Pharmaceutical Care & Health Systems
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Research Article

Role of Clinical Pharmacist to Reduce Risk in Patients Involving Antiretroviral Drugs at Abidjan Cohort

Djadji ATL1,2*, Kamenan BAT1,5, Kassi NAC2,3, Guehi C4, Bekegran C1,2 and Eholie SP2,3

1Clinical Pharmacy and Therapeutic laboratory, Pharmaceutical and Biological Faculty, Felix Houphouet Boigny’s University at Abidjan, Côte d’Ivoire 01 BPV 34 Abidjan, Ivory Coast

2Infectious and Tropical Diseases Unit of Treichville teaching Hospital at Abidjan, Côte d’Ivoire 01 BPV 03 Abidjan, Ivory Coast

3Medical Sciences Department, Felix Houphouet Boigny’s University at Abidjan, Côte d’Ivoire 01 BPV 34 Abidjan, Ivory Coast

4Advises and outpatient care Unit at Abidjan, Côte d’Ivoire

5Unit of Pneumophtisiology Cocody Teaching Hospital Abidjan

*Corresponding Author:
Djadji ATL
Clinical Pharmacy and Therapeutic laboratory
Pharmaceutical and Biological Faculty
Felix Houphouet Boigny’s University at Abidjan
Côte d’Ivoire 01 BPV 34 Abidjan 01
Tel: +22507797257
E-mail: [email protected]

Received date: June 04, 2016; Accepted da te: July 05, 2016; Published date: July 18, 2016

Citation: Djadji ATL, Kamenan BAT, Kassi NAC, Guehi C, Bekegran C and Eholie SP (2016) Role of Clinical Pharmacist to Reduce Risk in Patients Involving Antiretroviral Drugs at Abidjan Cohort. J Pharma Care Health Sys 3:165. doi:10.4172/2376-0419.1000165

Copyright: © 2016 Djadji ATL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: The rapid increase in access to antiretroviral therapy in developing countries has brought with it new challenges. The management of risk by the clinical pharmacist may improve HIV patient’s health in poor resources setting. We assessed risk criteria for drug-drugs interactions to inform clinicians. Methods: This transversal work included patients at the beginning of ART treatment. From January to August 2015, HIV seropositive attending for care at Infectious and Tropical diseases Unit of Treichville teaching Hospital at Abidjan. The guidelines for entry into the antiretroviral program has been used. All the coprescribed drugs were screened for potential for Drugs-Drugs significate interactions using the Liverpool HIV Pharmacology Group website (www.hiv-druginteractions.org). Also many others books and website have been used to analyse drugs interactions. Finally, the French Clinical pharmacy guideline allowed to stratify the pharmaceutical interventions. Results: Of 562 patients screened, 228 patients were included in the final analysis, comprising 91(39.91%) male and 137(60.9%) females; aged between 35-48 years (median 41 years), unmarried 160(63.18%), 218(95.61%) HIV1, 117(51.75%) with TB, renal failure 21(9.27%), First line of antiretroviral therapy 198 (86.84%) and 27(11.6%) patients were on second line treatment, Stage C (62.39%), mean Body mass index at baseline of 17.5.1 kg/m2 (range 35-48 kg). Baseline CD4 counts were 200 (IQR 25-75%) (Range 131.5-278) cells/mm3.The use of 1st line regimens were as follows: TDF/3TC/EFV in 141 patients (61.34%). Antiretroviral were prescribed at standard doses, regardless of whether a CR was present or not. Physiopathology stage was identified in 83 patients (36.41%) and potential drugs-drugs interactions with antiretroviral were identified in in 145 patients (63.59%) involving anti infectives for systemic use and anti-parasitic products 131(79.88%), 18(10.98%) traditional plants. The potentials interactions 120(52.63%), contraindicated 25(10.96%) and Biological monitoring 130(57.02%) followed by Substitution/Exchange 47(20.61%) were found. Conclusion: The role of pharmacist to manage patient’s health is very important to decrease the mortality or morbidity linked to HIV.

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