Role of Computed Tomography Coronary Angiography in the Detection of Vulnerable Plaque, Where Does it Stand Among Others?George Youssef* and Matthew Budoff
Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, California, USA
- *Corresponding Author:
- George Youssef
Los Angeles Biomedical Research Institute Harbor UCLA
1124 West Carson Street
Torrance CA 90503, USA
E-mail: [email protected]
Received Date: May 25, 2013; Accepted Date: July 26, 2013; Published Date: July 28, 2013
Citation: Youssef G, Budoff M (2013) Role of Computed Tomography Coronary Angiography in the Detection of Vulnerable Plaque, Where Does it Stand Among Others? Angiol 1:111. doi:10.4172/2329-9495.1000111
Copyright: © 2013 Youssef G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recently, there has been a growing interest in identification of coronary “vulnerable plaques” that are prone to rupture; this potentially would help identify patients with higher risk of development of cardiac events. Recent advances in cardiac imaging modalities have been successful in studying various plaque vulnerability features to variable degrees, strengths and limitations. Computed Tomography Coronary Angiography (CTCA) has gained an increasing popularity in studying plaque anatomy, morphology and composition by the virtue of its widespread availability and non-invasiveness. CTCA has been validated against histology and IVUS with reasonable correlation; moreover, some follow-up studies have shown a significant association to the development of acute coronary syndromes. Nevertheless, attention should be paid to the whole patient big picture that includes other factors operating on other extra-coronary axes that involve inflammation, immunity, coagulation and neuroendocrine systems.