Role of Curcumin in Treatment of Alzheimer DiseaseChitrangada Das Mukhopadhyay*, Bhuban Ruidas and Sutapa Som Chaudhury
Centre for Healthcare Science and Technology, Indian Institute of Engineering Science and Technology, Shibpur, West Bengal, India
- *Corresponding Author:
- Dr. Chitrangada Das Mukhopadhayay
Assistant Professor, Centre for Healthcare Science and Technology
Indian Institute of Engineering Science and Technology
Shibpur, West Bengal, India
E-mail: [email protected]; [email protected]
Received date: March 01, 2017; Accepted date: June 06, 2017; Published date: June 13, 2017
Citation: Mukhopadhyay CD, Ruidas B, Chaudhury SS (2017) Role of Curcumin in Treatment of Alzheimer Disease. Int J Neurorehabilitation 4:274. doi:10.4172/2376-0281.1000274
Copyright: © 2017 Mukhopadhyay CD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A lot of research findings support that curcumin (diferuloyl methane) has antioxidant, anti-inflammatory and antitumor activity. In India, curcumin has a widespread use as food additive and herbal medicine for human diseases without any side effect. Though curcumin is well established as an anticancer agent but there are a few reports about its promising role against amyloid diseases. According to recent finding curcumin play a crucial inhibitory role in pathophysiology of Alzheimer’s disease (AD). Oral administration of curcumin or its metabolites has shown the inhibition of Aβ deposition, Aβ oligomerization and tau phosphorylation in the brain of AD animal model including behavioural improvement. But still it is unknown whether the curcumin is directly involved in those processes or enhance those mechanisms. Thus in this review we want to focus on overall mechanism of curcumin in AD. Some strategies to overcome the problem of low absorption and fast clearance of curcumin nanoparticles have also been proposed.