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Review Article

Role of Cytokines in Heart Failure

Santosh Kumar1* and Subir Maulik2

1Department of Internal Medicine, University of Iowa, IA 52242, USA

2Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

*Corresponding Author:
Kumar S
Associate, Cardiovascular Medicine
Department of Internal Medicine
University of Iowa
IA 52242, USA
Tel: +1 319-335-3500
E-mail: [email protected]

Received Date: May 17, 2017; Accepted Date: June 07, 2017; Published Date: June 14, 2017

Citation: Kumar S, Maulik S (2017) Role of Cytokines in Heart Failure . J Pharmacol Rep 2:123.

Copyright: © 2017 Kumar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Inflammation regulates myocardial function and cytokines are considered as its key regulator. There is abundant literature suggesting that cytokines have been known to directly regulate cardiac function. However, the evidence of such regulation failed to go through the transition from bench to bedside. Large clinical trials aimed at investigating the impact of anti-cytokine therapy on heart failure failed to bring a significant change in the end points. Here we will summarize the available proof from preclinical and clinical studies.

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