Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in DiabetesHaobo Li1, Micheael G Irwin1,2, Mingzhe Tao3, Yalan Li3, Liangqing Zhang4 and Zhengyuan Xia1,2,4*
- *Corresponding Author:
- Zhengyuan Xia
Department of Anesthesiology
The University of Hong Kong
102 Pokfulam Road, Hong Kong, SAR, China
Tel: (852) 28199794
Fax: (852) 28199791
E-mail: [email protected]
Received date: January 03, 2013; Accepted date: February 06, 2013; Published date: February 10, 2013
Citation: Li H, Irwin MG, Tao M, Li Y, Zhang L, et al. (2013) Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes. J Diabetes Metab 4:247. doi:10.4172/2155-6156.1000247
Copyright: © 2013 Li H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Diabetes, characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance, is a chronic metabolic disorder. Hearts of subjects with diabetes are more sensitive to myocardial ischemia/reperfusion injury but the underlying mechanism is largely unclear. Recent evidence suggests that alteration in cardiac metabolism is a key contributor to the increased vulnerability of diabetic heart to ischemia/reperfusion injury. The FoxO family of forkhead transcription factors including FoxO1, 3 and 4 play important roles in the regulation of many cellular and biological processes and are critical regulators of cardiac metabolism and cellular oxidative stress in the heart. This brief review focuses on the role of FoxO in regulating cardiac metabolism and its association with myocardial ischemia/reperfusion injury, especially in diabetes.