alexa Role of IL-21 in Systemic Lupus Erythematosus | OMICS International
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Role of IL-21 in Systemic Lupus Erythematosus

Sonia S. Jung and Heath M. Guay*
Immunology Research, Centocor Research & Development, a Division of Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Radnor, PA USA
Corresponding Author : Heath M. Guay
Immunology Research, Centocor R & D
145 King of Prussia Rd
Mailstop R-4-1, Radnor, PA 19087
Tel: 610-651-6197
Fax: 610-240-4064
E-mail: [email protected]
Received June 15, 2011; Accepted September 10, 2011; Published September 13, 2011
Citation: Jung SS, Guay HM (2011) Role of IL-21 in Systemic Lupus Erythematosus. J Clin Cell Immunol S1:002. doi:10.4172/2155-9899.S1-002
Copyright: © 2011 Jung SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Systemic lupus erythematosus is a chronic autoimmune disease that affects multiple organ systems and tissues. Activation and differentiation of autoreactive T and B cells, and the formation of pathogenic autoantibodies are central to disease pathogenesis. IL-21 is the most recently identified member of the family of cytokines whose receptors share the common γc. IL-21 is a pleotropic cytokine that regulates the activation, differentiation and expansion of B and T cells. Here, we review the role of IL-21 in T and B cell biology, and provide insight into the potential role of IL-21 in the development of SLE.

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