Role of lrp in the Pseudomonas Aeruginosa Small Colony Formation
Dinesh Diraviam Sriramulu*
Division of Cell and Immune Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany, 38124 Braunschweig, Germany
- *Corresponding Author:
- Dr. Dinesh Diraviam Sriramulu
CIBIO-University of Trento
Via della Regole 101, Mattarello
(TN) 38060, Italy
Tel: +39 461 883093
Fax: +39 461 883937
E-mail: [email protected]
Received Date: February 17, 2009; Accepted Date: March 13, 2009; Published Date: March 13, 2009
Citation: Sriramulu DD (2009) Role of lrp in the Pseudomonas Aeruginosa Small Colony Formation. J Proteomics Bioinform 2: 131-138. doi: 10.4172/jpb.1000070
Copyright: © 2009 Sriramulu DD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Formation of small colonies and slow growth are among common features of Pseudomonas aeruginosa isolated from the lung of cystic fibrosis (CF) patients. A slowgrowing CF lung isolate strain C that was complemented with the whole-genome cosmid library, created from an environmental isolate, revealed the role of leucine-responsive regulatory protein on the colony size, the growth and the proteome profile. Sequence analysis of lrp and its homologues in strain C revealed a mutation in the homologue PA3965 compared to the respective sequence of PAO. In addition to the regulation of enzymes involved in amino acid biosynthesis and metabolism, Lrp seemed to regulate the expression of chaperones (DnaK, GroEL and GroES) and the suppressor protein DksA.