Role of Mucosal Colonic Biopsy in Patients with Chronic Unexplained Diarrhoea who their Colonoscopy is NormalDalia M Badary1* and Mohamed Z Hafez2
- *Corresponding Author:
- Dalia M Badary
Assuit University Al-Gamaa Street, Egypt
E-mail: [email protected]
Received date: January 31, 2017; Accepted date: February 6, 2017; Published date: February 13, 2017
Citation: Badary DM, Hafez MZ (2017) Role of Mucosal Colonic Biopsy in Patients with Chronic Unexplained Diarrhoea who their Colonoscopy is Normal. Mol Biol 6:185. doi:10.4172/2168-9547.1000185
Copyright: © 2017 Badary DM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: We sought to determine the importance of histopathological assessment in patients with chronic diarrhoea who had macroscopically normal colonic endoscopies. Methods: Of 300 consecutive patients undergoing colonoscopy by one endoscopist during a five year period, biopsies were taken in 200 cases of unexplained diarrhoea of at least 6 weeks and their colorectal mucosa appeared macroscopically normal. All biopsies were reviewed by one pathologist. Results: Of the 200 patients enrolled, 36 (18%) cases were classified as unremarkable histopathological diagnosis and 164 (82%) cases showed histopathological changes: 121 (73.78%) non-specific inflammation, 19 (11.58%) ulcerative colitis, 11 (6.7%) collagenous colitis, 7 (4.26%) lymphocytic colitis, and 6 (3.65%) bilharzial colitis. Conclusion: We conclude that the role of biopsies in chronic diarrhoea patients with grossly normal colon at endoscopy is high as yielding a histological diagnosis in 21.5% of patients is so benefit to them as they may had modified the therapy received after identification of a specific cause as collagenous colitis, lymphocytic colitis, ulcerative colitis and bilharzial colitis. So Patients should be subject to colonoscopy and biopsy to aid specific diagnoses.