alexa Role of Peroxisome Proliferator Activator Receptor γ in Diabetic Retinopathy Pathophysiology | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Review Article

Role of Peroxisome Proliferator Activator Receptor γ in Diabetic Retinopathy Pathophysiology

Min K Song, Basil D Roufogalis* and Tom H.W Huang*

Herbal Medicines Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia

*Corresponding Authors:
Tom Hsun-Wei Huang
Faculty of Pharmacy
The University of Sydney
NSW 2006 Australia
Tel: +61 2 9351 3234
E-mail: [email protected]

Basil D Roufogalis
Faculty of Pharmacy
The University of Sydney
NSW 2006 Australia
Tel: +61 2 9351 2360
Fax: +61 2 9351 4391
E-mail: [email protected]

Received date November 30, 2011; Accepted date February 18, 2012; Published date February 23, 2012

Citation: Song MK, Roufogalis BD, Huang THW (2012) Role of Peroxisome Proliferator Activator Receptor γ in Diabetic Retinopathy Pathophysiology. J Diabetes Metab S3:005. doi:10.4172/2155-6156.S3-005

Copyright: © 2012 Song MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Diabetic retinopathy (DR) is one of the most common complications of diabetes and one of the leading causes of blindness worldwide. DR involves an abnormal pathology of major retinal cells, including retinal pigment epithelium, vascular cells (endothelial cells and pericytes), retinal microglial cells and retinal ganglion cells. The biochemical mechanisms associated with hyperglycemic-induced DR are through multifactorial processes. Peroxisome proliferatoractivated receptor-γ ( PPAR-γ) plays an important role in the pathogenesis of DR by inhibiting diabetes-induced retinal leukostasis and leakage. Despite DR causing eventual blindness, only a few visual or ophthalmic symptoms are observed until visual loss develops. Laser photocoagulation therapy is the most common treatment. However, this therapy may cause retinal damage and scarring. Therefore, early medical interventions and prevention are the current management strategies. The recent advancements in the knowledge of the pathogenic alterations driving ocular damage and vision loss in DR strongly focus on PPAR-γ as a valuable target to control high glucose-induced inflammation and apoptosis. This review provides an analysis of potential involvement of PPAR-γ in various mechanisms and pathways associated with progression of DR.

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