alexa Role of Serum Cholesterol Level in Pathogenesis of OCD
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
Open Access

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Research Article

Role of Serum Cholesterol Level in Pathogenesis of OCD

Madhura TK*

Deapartment of Biochemistry, Defense Institute of Advanced Technology, Near Khadakwasla Dam, Girinagar, Pune 411025, India

*Corresponding Author:
Madhura TK, MBBS, MD (Biochemistry)
Defense Institute of Advanced Technology
Near Khadakwasla dam, Girinagar, Pune 411025, India
Tel: 9921041635
E-mail: [email protected]

Received Date: May 15, 2015; Accepted Date: May 20, 2015; Published Date: May 22, 2015

Citation: Madhura TK (2015) Role of Serum Cholesterol Level in Pathogenesis of OCD Biochem Anal Biochem 4:183. doi:10.4172/2161-1009.1000183

Copyright: © 2015 Madhura TK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Etiology and pathophysiology of obsessive compulsive disorder remains inconclusive till today. Multiple converging lines of evidence suggest that neurobiology plays a significant role in the etiology of obsessive compulsive disorder (OCD). Certain brain areas frequently involved in symptomatology of OCD, analyzed by neuroimaging studies. The strongest pharmacologic evidence concerns the serotonergic system and the well-established efficacy of potent serotonin reuptake inhibitors in the treatment of OCD. Cholesterol forming the vital component of neurons regulates neurochemical activity. Reduced serum cholesterol level causes hyperactivity of serotonin reuptake receptor activity precipitating symptoms of OCD.


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