alexa Role of Thymidinekinase and Thymidine Phosphorylase as Enzymatic Test for Efficacy of Oncological Patients Treatment
ISSN: 2153-0769

Metabolomics:Open Access
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Research Article

Role of Thymidinekinase and Thymidine Phosphorylase as Enzymatic Test for Efficacy of Oncological Patients Treatment

Berta G Borzenko*, Elena M Bakurova, Kseniia A Mironova, Yuliya D Tursunova and Yuriy V Dumanskiy

Department of Chemistry, Maksim Gorky Donetsk National Medical University, Donetsk, Ukraine

*Corresponding Author:
Berta Georgievna Borzenko
Department of Chemistry
M. Gorky National Medical University
Pr. Illicha 16, Donetsk, 83003, Ukraine
Tel: 067-621-25-75
E-mail: [email protected]

Received date: July 09, 2013; Accepted date: August 27, 2013; Published date: September 02, 2013

Citation: Borzenko BG, Bakurova EM, A Mironova K, Tursunova YD, Dumanskiy YV (2013) Role of Thymidinekinase and Thymidine Phosphorylase as Enzymatic Test for Efficacy of Oncological Patients Treatment. Metabolomics 3:123. doi: 10.4172/2153-0769.1000123

Copyright: © 2013 Borzenko BG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The treatment of breast cancer has been undergoing an incredible sequence of changes. The role of individual treatment of women with breast cancer is not clearly defined. Since last century the drug 5-fluorouracil with another anticancer agents and prodrugs from group of fluoropyrimidines are widely used. Thymidine phosphorylase is the enzyme which can also catalyze the interconversion of uracil as well as several fluoropyrimidines. Thymidine Phosphorylase (TP) and Thymidine Kinase (TK) also play an important role in thymidine homeostasis and thus in DNA synthesis. Thymidine kinase is used as cells proliferation marker. Thymidine phosphorylase is similar to the platelet-derived endothelial cells growth factor. High expression of the enzyme is related to malignant angiogenesis and invasion. That is why we investigated the activity of TK and TP both in healthy women and patients with breast cancer (BC) of the I–IV stages and of the same age. Analysis of biochemical and morphological data of these patients revealed that the patients are initially divided according to the activity of blood plasma TP also had different morphological structure of the tumor. In the 1-st group the initial activity of TP was sharply reduced and in the 2nd group TP activity ranged normally. During the treatment of women from the 1st group the activity of TP was not changed, but the activity of TK was increased 3 times. In patients from the 2nd group the activity of TP was authentically increased, but TK activity was reduced. The follow-up analysis showed that four-year lethality in the 1-st group constituted 25%, and there was no lethality in the the 2nd group. Therefore the studied enzymes activity may be used as the informative test for monitoring of patients with breast cancer and optimization of drug treatment.

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