alexa Role of Thyroid Hormones in Different Aspects of Cardiovascular System
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

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Review Article

Role of Thyroid Hormones in Different Aspects of Cardiovascular System

Vargas U Hernando* and Morales S Eliana

Division of Endocrinology and Metabolism, Internal Medicine Department, University of Cauca, Popayán-Cauca, Colombia

*corresponding Author:
Vargas U Hernando
Division of Endocrinology and Metabolism
University of Cauca Popayán-Cauca
Hospital Universitario San José
Carrera 6 No 10N-142 3er piso, Colombia, USA
Tel: 8234508
Fax: 8234712
E-mail: [email protected]

Received Date: February 03, 2015; Accepted Date: March 13, 2015; Published Date: March 23, 2015

Citation: Hernando VU, Eliana MS (2015) Role of Thyroid Hormones in Different Aspects of Cardiovascular System. Endocrinol Metab Synd 4:166. doi:10.4172/2161-1017.1000166

Copyright: © 2015 Hernando VU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Besides its metabolic and thermoregulatory tissue effects, thyroid hormones plays a fundamental role in the cardiovascular homeostasis, mediated by genomic and non-genomic effects. Consequently, thyroid hormones deficits, as well as excesses, are expected to result in profound changes in cardiac function regulation and cardiovascular hemodynamics. Hyperthyroidism induces a hyperdynamic cardiovascular state, which is associated with enhanced left ventricular systolic, diastolic function, and the chronotropic and inotropic properties of thyroid hormones. On the other hand; in a hypothyroid state, thyroid hormones deficiency results in lower heart rate and weakening of myocardial contraction and relaxation, with prolonged systolic and early diastolic times. Subclinical hypothyroidism is characterized by abnormal lipid metabolism and cardiac dysfunction; diastolic hypertension conferring an elevated risk of atherosclerosis, and ischemic heart disease. The risk of cardiovascular mortality and atrial fibrillation [but not other outcomes] in subclinical hyperthyroidism is higher among patients with very low levels of thyrotropin. Finally, medications such as amiodarone may induce hypothyroidism [mediated by the Wolff-Chaikoff] as well as hyperthyroidism [mediated by the Jod-Basedow effect]. In both instances, the underlying cause is the high concentration of iodine in this medication.

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