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Role of Tumor Suppressor Protein p53 in Apoptosis and Cancer Therapy | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Review Article

Role of Tumor Suppressor Protein p53 in Apoptosis and Cancer Therapy

Naga Deepthi CH1*, VVL Pavan Kumar A2, Rameshbabu3 and U Indirapriyadarshini4
1Department of Microbiology, Andhra University, India
2Department of Bioinformatics, Bharath University, Chennai, India
3Department of Biochemistry, Gitam University, India
4Department of biotechnology/Indonesia cancer institute, Osmania University, Hyderabad-500017, India
Corresponding Author : Naga Deepthi CH
Department of Microbiology
Andhra University, India
E-mail: [email protected]
Received May 15, 2011; Accepted July 15, 2011; Published July 18, 2011
Citation: Naga Deepthi CH, VVL Pavan Kumar A, Rameshbabu, Indirapriyadarshini U (2011) Role of Tumor Suppressor Protein p53 in Apoptosis and Cancer Therapy. J Cancer Sci Ther S17:001. doi:10.4172/1948-5956.S17-001
Copyright: © 2011 Naga Deepthi CH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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TP53, encoding p53, is one of the most famous tumor suppressor genes. The majority of human cancers demonstrate the inactivation of the p53 pathway. Mutant p53 not only, no longer, functions as a tumor suppressor but can also exert tumor-promoting effects. The basic function of p53 is to respond to cellular stress. We here in this review article discusses about the recent advances in p53 research, mainly focusing on apoptosis and therapy for human cancer. Hence, this review aims to update the current related articles and provide a further understanding about such molecular changes relevant to trigger imbalances in the regulation of apoptosis in cancer.


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