Role of Vitamin D in Various Illnesses: A ReviewPramil Tiwari* and Nidhi Sharma
Department of Pharmacy Practice, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, 160062, India
- *Corresponding Author:
- Pramil Tiwari
Department of Pharmacy Practice
National Institute of Pharmaceutical Education and Research (NIPER)
S.A.S. Nagar, Punjab, 160062, India
E-mail: [email protected]
Received date: May 29, 2017; Accepted date: June 15, 2017; Published date: June 22, 2017
Citation: Tiwari P, Sharma N (2017) Role of Vitamin D in Various Illnesses: A Review. J Pharma Care Health Sys 4:176. doi: 10.4172/2376-0419.1000176
Copyright: © 2017 Tiwari P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Vitamin D, a fat-soluble vitamin, concentrations need to be maintained for functioning of the metabolic, immune, reproductive, muscular, skeletal, respiratory and cutaneous systems of men and women of all ages. A rough estimate indicates that about 1 billion people globally are vitamin D deficient. The physiological functions of active vitamin D (calcitriol) are related to calcium homeostasis and osteoporosis, with possible roles in diabetes, cancer, ischemic heart disease, and autoimmune and infectious diseases. Vitamin D deficit increases the risk of malignancies, particularly of colon, breast and prostate gland, of chronic inflammatory and autoimmune diseases (e.g. insulin-dependent diabetes mellitus, inflammatory bowel disease, multiple sclerosis), as well as of metabolic disorders (metabolic syndrome, hypertension). The eight disorders discussed in this review are heart disease, bone disorder, colorectal cancer and other malignancies, infectious, inflammatory and autoimmune diseases, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis and type-I diabetes mellitus. There is a strong evidence for association between heart diseases, bone disorders, colorectal cancers, infectious, inflammatory and autoimmune diseases, inflammatory bowel diseases, multiple sclerosis, diabetes mellitus type-I and vitamin D. the extent of vitamin D deficiency’s contribution in the development of osteoporosis, breast cancer, rheumatoid arthritis is unclear.