Rs4676410 and Rs2531875 are Associated with the Risk of Ankylosing Spondylitis in the Han Chinese PopulationQingwen Wang1, Ping Li2, Jing Wang1, Qi Lin1, Luo Wang2 and Zhengyu Fang1,2*
- *Corresponding Author:
- Zhengyu Fang
Biomedical Research Institute
Shenzhen Peking University
The Hong Kong University of Science and Technology Medical Center
Guangdong 518036, China
E-mail: [email protected]
Received Date: May 19, 2014; Accepted Date: September 27, 2014; Published Date: October 8, 2014
Citation: Wang Q, Li P, Wang J, Lin Q, Wang L (2014) Rs4676410 and Rs2531875 are Associated with the Risk of Ankylosing Spondylitis in the Han Chinese Population. Rheumatology (Sunnyvale) S5:007. doi: 10.4172/2161-1149.S5-007
Copyright: © 2014 Qingwen W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: Although the exact cause of ankylosing spondylitis (AS) is unknown, genetics play a key role in AS. A recent genome-wide association study identified new immune-related susceptibility loci for AS in East Asians, and these need to be validated in the Chinese population. Methods: We enrolled 848 patients who met the modified New York criteria for AS and 1123 healthy normal controls in the present study. High-resolution melting analysis accompanied with sequencing was carried out to genotype five polymorphisms: rs12615545, rs4676410, rs1250550, rs2531875, and rs7282490. Distributions of genotypes and alleles were compared between AS patients and healthy controls, and among AS patients stratified by clinical parameters, age, and gender. Results: rs4676410 (p=0.0237; odds ratio (OR): 1.109; 95% confidence interval (CI): 1.014–1.213) and rs2531875 (p=0.0308; OR: 1.117; 95% CI: 1.01–1.234) were both associated with the risk of AS. However, no association was found between the studied polymorphisms and AS severity. An association between the rs4676410T allele and iridocyclitis was observed (p=0.0142; OR: 1.403; 95% CI: 1.11–1.774). Conclusion: rs4676410 and rs2531875 are associated with AS susceptibility in the Han Chinese population. The rs4676410T allele might be correlated with iridocyclitis.