alexa Salivary Peptidomic Analysis -The Extension of Proteomics

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Salivary Peptidomic Analysis -The Extension of Proteomics

Jieni Zhang1, Xueji Zhang2, Qingwei Ma2, Jiuxiang Lin1* and Feng Chen3*

1Department of Orthodontics, School of Stomatology, Peking University, Beijing 100081, P.R. China

2BioyongTech, Technology, Beijing 100080, P.R. China

3Central Laboratory, School of Stomatology, Peking University,Beijing 100081, P.R. China

*Corresponding Author:
Jiuxiang Lin
Central Laboratory, School of Stomatology
Peking University, #22 Zhongguancun South Road
Haidian District, Beijing 100081,PR China
Fax: +86 010 82195536
E-mail: [email protected]

Feng Chen
Department of Orthodontics, School of Stomatology
PekingUniversity, #22 Zhongguancun South Road
Haidian District, Beijing 100081, P R China
E-mail: [email protected]

Received date: March 26, 2013; Accepted date: April 25, 2013; Published date: April 29, 2013

Citation: Zhang J, Li Y, Ma Q, Lin J, Chen F (2013) Salivary Peptidomic Analysis-The Extension of Proteomics. J Mol Biomark Diagn 4:142. doi: 10.4172/2155-9929.1000142

Copyright: © 2013 Zhang J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Nowadays, proteomic-related studies have developed rapidly and improvement has been made in the scientific and technological fields. Besides the proteome, the peptidome with low molecular weight has apparently attracted increasing attention in recent years too. The peptidome performs a large array of vital biological functions to contribute to homeostasis in the certain tissues. However, due to the interference by high-abundance proteins in complex biological body fluids such as saliva and serum, selective enrichment of peptides with low molecular weight is the first and most important step before analyzing the peptidome. This review mainly illustrates the general concept of the peptidome, specific methods of saliva collection, advanced peptidomic technologies and the recently developed peptidomic-related reports, as well as some limitations of the application in salivary peptidome. The future prospects of the peptidome are also involved.

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