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Salivary Stress Markers, Depression, Mood State and Back Pain in Healthy Men in Two Bed Rest Conditions: Validation of Two Models for Human Space Flight | Abstract
ISSN: 2168-9792

Journal of Aeronautics & Aerospace Engineering
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Research Article

Salivary Stress Markers, Depression, Mood State and Back Pain in Healthy Men in Two Bed Rest Conditions: Validation of Two Models for Human Space Flight

Balwant Rai1* and Jasdeep Kaur2
1Simulated microgravity and human body, JBR Institute of Health Education Research and Technology, India and Kapler Space University, South Carolina, USA
2JBR Institute of Health Education Research and Technology, Punjab, India
*Corresponding Author : Balwant Rai
President, Simulated microgravity and human body
JBR Institute of Health Education Research & Technology, India
E-mail: [email protected]
Received July 17, 2012; Accepted November 20, 2012; Published November 22, 2012
Citation: Rai B, Kaur J (2013) Salivary Stress Markers, Depression, Mood State and Back Pain in Healthy Men in Two Bed Rest Conditions: Validation of Two Models for Human Space Flight. J Aeronaut Aerospace Eng 2:105. doi: 10.4172/2168-9792.1000105
Copyright: © 2013 Rai B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The NASA promise to long-duration space flight includes astronauts who will be returning to the moon as well as those who will take part in human missions to Mars. Successful exploration will require a better understanding of the effects that extended missions pose for the behavioral health of astronauts, not just during flight but also pre and post-flight. The potential for psychiatric disorders developing in long-duration crews during or after missions requires that consideration be given to prevention and treatment .The objective of this study was to validate a ground-based models (Two bed rest conditions such as 6° head-down tilt (HDT) and bed rest position (HB) for microgravity and zero gravity and to study the effects of simulated condition on depression, mood state, back pain and biochemical stress markers. The aim of the present study was to determine the effects of 20-day HDT & HB on psychic stress, depression, mood-state, backache and headache in 10 healthy male volunteers. Psychological state was assessed by a stress test, mood state and cortisol was measured in saliva. During HDT and HB, all volunteers developed psychic stress, and the diurnal rhythm of cortisol secretion was significantly increased in simulated conditions. In addition, urine excretion of dopamine, epinephrine and norepinephrine were significantly increased. Thus 6° HDT & HB appears to be a valid model to induce psychic stress and neuroendocrine-related changes that could also be encountered by astronauts and marsonaunts during long-duration spaceflights.


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