Salvage Liver Transplantation for HCC: An Old Story without Consensus?
- *Corresponding Author:
- Gonzalo Sapisochin
Department of HBP Surgery & Transplantation
Hospital Universitario Vall d´Hebron
E-mail: [email protected]
Received Date: July 27, 2011; Accepted Date: October 31, 2011; Published Date: November 04, 2011
Citation: Sapisochin G, Charco R (2011) Salvage Liver Transplantation for HCC: An Old Story without Consensus? J Transplant Technol Res 1: 106e. doi: 10.4172/2161-0991.1000106e
Copyright: © 2011 Sapisochin G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hepatocellular carcinoma (HCC), the most common liver tumor is a leading cause of mortality, accounting for more than 1 million deaths annually. Most HCC are diagnosed in association with liver cirrhosis, with the main risk factors being hepatitis B and C and alcohol abuse. In the past, HCC was diagnosed at advanced stages; no treatment could be applied and the prognosis was poor. Fortunately, as a result of screening programs in high-risk populations, patients with HCC are now diagnosed at an early stage, and up to 30% can be considered for a curative treatment. These curative treatments include liver resection (LR), liver transplantation (LT) and percutaneous ablation . LT is the most effective treatment for patients with HCC since it removes the tumor and surrounding cirrhotic tissue, the main risk factor for the development of new tumors. Following the Milan criteria (single tumors = 5 cm or 3 tumors all of them = 3 cm), up to 75% 4-year survival has been described with a low recurrence rate (<10%) constituting the most extended criteria for LT for HCC . Some groups have developed expanded criteria for LT for HCC such as the UCSF criteria and the up-to-seven criteria, with acceptable results.