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Sample Size Calculation for the Modified Likelihood Ratio Test in Genetic Linkage Analysis | OMICS International | Abstract
ISSN: 2155-6180

Journal of Biometrics & Biostatistics
Open Access

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Research Article

Sample Size Calculation for the Modified Likelihood Ratio Test in Genetic Linkage Analysis

Yuejiao Fu*, Pengfei Li and Soowoon Chung

York University and University of Waterloo, Canada

*Corresponding Author:
Yuejiao Fu
York University and University of Waterloo, Canada
Tel: 416-736-2100 ext. 33772
Fax: 416-736-5757
E-mail: [email protected]

Received date: July 01, 2014; Accepted date: August 07, 2014; Published date: August 11, 2014

Citation: Fu Y, Li P, Chung S (2014) Sample Size Calculation for the Modified Likelihood Ratio Test in Genetic Linkage Analysis. J Biom Biostat S12:002. doi:10.4172/2155-6180.S12-002

Copyright: © 2014 Fu Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are are credited.

Abstract

Mixture models provide flexible means of handling heterogeneity in data. The possible latent structure suggested by mixture model analysis should be carefully examined using designed experiments. Sample size determination is an important and difficult step in design of experiments. We investigate the sample size calculation for the modified likelihood ratio test for binomial mixture models arising in genetic linkage analysis. We obtain limiting distributions for the modified likelihood ratio test under two sets of commonly used local alternatives. A simple sample-size formula is obtained and illustrated using both simulations and a genetic linkage study for schizophrenia.

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