Sapiens Mitochondrial DNA Genome Circular Long Range Numerical Meta Structures are Highly Correlated with Cancers and Genetic Diseases mtDNA Mutations
IBM emeritus, Martignas Bordeaux metropole, France
- *Corresponding Author:
- Jean-claude Perez
PhD Maths and Computer Science
retired interdisciplinary researcher (IBM emeritus)
7 avenue de terre-rouge F33127 Martignas
Bordeaux metropole, France
Tel: 33 0781181112
E-mail: [email protected], [email protected]
Received date: May 19, 2017; Accepted date: June 07, 2017; Published date: June 12, 2017
Citation: Perez JC (2017) Sapiens Mitochondrial DNA Genome Circular Long Range Numerical Meta Structures are Highly Correlated with Cancers and Genetic Diseases mtDNA Mutations. J Cancer Sci Ther 9:512-527. doi: 10.4172/1948-5956.1000469
Copyright: © 2017 Perez JC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Using the circular nature of the 16k base-pairs human mtDNA genome, we are looking for hypothetical proportions between the C+A and T+G bases. Remarkable proportions are thus discovered, the length of which may be much greater than the length of the genome. We then analyze the impact of evolution on these “numerical resonances” by comparing the referenced mtDNAs of Sapiens, Neanderthal and Denisova. Then, by analyzing 250 characteristic mutations associated with various pathologies, we establish a very strong formal causal correlation between these numerical meta structures and these referenced mutations. To summarize, we should think then research on the following situation: (a) Inputs: 250 cases of mtDNA mutations1 associated with various human diseases. (b) An operator: The exhaustive search for mtDNA genome “Fibonacci resonances” associated with these mutations. (c) A “binary” output: a common behavior of the mtDNA genome resulting from these 250 mutations disorders.