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Sciatic Nerve Neuropathy in Cynomolgus Monkey Macaca Fascicularis: Altered Leg Usage and Peripheral Nerve Firing | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Sciatic Nerve Neuropathy in Cynomolgus Monkey Macaca Fascicularis: Altered Leg Usage and Peripheral Nerve Firing

Ning Guo1,2, Xiyao Gu3, Yikuan Xie4, Jun Zhao3, Qinglian Xie5, Guoping Zhao5, Meilei Jin5, Zhiqi Zhao3, Hong Zou5, Yuqiu Zhang3, Gang Jason Jin2, Lei Yu6*

1Shanghai University of Traditional Chinese Medicine, Shanghai, China

2ShanghaiBio Corporation, 675 US Highway One, North Brunswick, New Jersey 08902, USA

3Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China

4Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China

5Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

6Department of Genetics & Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, New Jersey 08854, USA

Corresponding Author:
Lei Yu
Department of Genetics & Center of Alcohol Studies
Rutgers University, 607 Allison Road
Piscataway, New Jersey 08854, USA
Tel :+1-848-445-0794
Fax: +1-732-445-3500
E-mail: [email protected]

Received date: September 25, 2014; Accepted date: November 18, 2014; Published date: November 22, 2014

Citation: Guo N, Gu X, Xie Y, Zhao J, Xie Q, et al. (2014) Sciatic Nerve Neuropathy in Cynomolgus Monkey Macaca Fascicularis: Altered Leg Usage and Peripheral Nerve Firing. 5:247. doi:10.4172/2155-9562.1000247

Copyright: © 2014 Guo N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Sciatic nerve is susceptible to trauma and injuries. Animal models for sciatic nerve trauma are mostly in rodents,
with limited information about injury-induced neuropathy in non-human primates. We constructed a model of sciatic
nerve neuropathy (SNN) in the cynomolgus macaque monkey, Macaca fascicularis, with mild injury to, but without
transection of, the sciatic nerve. Monkeys’ behavioral and physiological properties were characterized. SNN led to
reduced leg usage as well as muscle atrophy. Sciatic nerve retained the ability of nerve signal transduction, and
showed a flat-line type of firing rate profile, consistent with the hypothesis of injury-resulted hyper-sensitization.
These data suggest that mild injury to sciatic nerve result in long-lasting malfunction and neuropathy in monkeys.
This model may serve as a non-human primate model to study functional changes, as well as underlying
pathological mechanisms, of traumatic injury to the sciatic nerve.


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