alexa Sclero-Resistance, Sclero-Sensibility and Sclero-Sensitization: The Role of the Tunica Adventitia in Sclerotherapy | OMICS International | Abstract
ISSN: 2155-9627

Journal of Clinical Research & Bioethics
Open Access

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Research Article

Sclero-Resistance, Sclero-Sensibility and Sclero-Sensitization: The Role of the Tunica Adventitia in Sclerotherapy

Ferrara F1* and Ferrara G2

1Studio Flebologico Ferrara, Italy

2Pharmacy Ferrara, Durazzano-Bn, Italy

*Corresponding Author:
Ferrara F
Studio Flebologico Ferrara 23
via Kuliscioff, 80011 Acerra -Na Italy
Tel: 0039-Off: 081/520723, 3356212337
Fax: 081/0603357
E-mail: [email protected]

Received date: February 17, 2014; Accepted date: April 20, 2014; Published date: April 28, 2014

Citation: Ferrara F, Ferrara G (2014) Sclero-Resistance, Sclero-Sensibility and Sclero-Sensitization: The Role of the Tunica Adventitia in Sclerotherapy. J Clinic Res Bioeth 5:181. doi: 10.4172/2155-9627.1000181

Copyright: © 2014 Ferrara F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The aim of this study was to assess the importance of the tunica adventitia in sclerotherapy, measuring sclero-resistance, sclero-sensitivity and sclero-sensitization parameters.

Materials and Methods

900 cases of Great Saphenous Vein (GSV) varicosity treated with Sigg-method sclerotherapy were examined for sclero-resistance as indicated by an ultrasound sclero-resistance marker (SRM+). Sclero-sensitivity was assessed by contact thermography in 356 cases of GSV varicosity with collagen alterations treated with Sigg sclerotherapy. Sclero-sensitization and treatment efficacy were assessed in 50 cases of non-reflux related telangiectasias recurring after a first course of foam microsclerotherapy and retreated with a second sclerotherapy regimen administered together with intradermal glycosaminoglycans (GAG).


Indicative of incomplete parietal fibrosis, the ultrasound marker SRM+ was most frequently found among patients with recurrence. The degree of sclero-sensibility was found to be inversely proportional to proteoglycan concentrations in the Ground Substance (GS), which in turn was seen to present in differing amounts in the various connective tissue diseases. Sclerotherapy combined with the administration of GAGs proved significantly effective in the treatment of recurrent telangiectasias, indicating GAG sclero-sensitizing properties


The efficacy of sclerotherapy depends on eliciting a regular fibrotic reaction starting from the connective tissue of the adventitia, which is modulated by ground substance GAG metabolism.


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