alexa Scoring System for Analyzing Vessel Development in Embryoid Bodies
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Research Article

Scoring System for Analyzing Vessel Development in Embryoid Bodies

Timo Schinköthe1 and Annette Schmidt2,3*

1Institute for Innovation and Medicine, Munich, Germany

2Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany

3Department of Molecular and Cellular Sport Medicine, German Sport University, Cologne, Germany

*Corresponding Author:
Dr. Annette Schmidt
Ph.D, Department of Molecular and Cellular Sport Medicine
German Sport University, Cologne, Germany
Tel: +49899926922931
Fax: +49899926922333
E-mail: [email protected]

Received date: November 30, 2015; Accepted date: January 28, 2016; Published date: January 31, 2016

Citation: Schinköthe T, Schmidt A (2016) Scoring System for Analyzing Vessel Development in Embryoid Bodies. J Stem Cell Res Ther 6:325. doi:10.4172/2157-7633.1000325

Copyright: © 2016 Schinköthe T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Embryoid bodies (EB) derived from pluripotent embryonic stem cells (ES) are powerful tools for different purposes. One interesting aspect is vessel development and the use for simulating angiostatic effects of drugs. Unfortunately, it is difficult to compare the impacts of different drugs. Current methods allow the description of observations, but quantifying methods are missing. To overcome that gap, we have developed a score system to transfer microscopic observations into quantifiable values. The score system summarizes different vessel characteristics within few categories and allows the comparison of drug effects in view of time and dosage. We analysed score behaviour with respect to normal vessel development as well as under presence of angiotstatic drugs. The vessel score showed a time-dependent increase under normal conditions while under presence of an angiogenesis-inhibitor the score increase was slowed, and under angiogenesis enhancing conditions the score increase was accelerated. The presented vessel development score seems to be a helpful tool to transfer microscopic observations in EB vessel development into a quantifiable and comparable value.

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