alexa Screening of Novel Natural Product Derived Compounds for Drug Discovery in Inflammation
ISSN: 2329-9029

Journal of Plant Biochemistry & Physiology
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Research Article

Screening of Novel Natural Product Derived Compounds for Drug Discovery in Inflammation

Shinjini Mitra, Srabani Kar, Konsam Surajlata and Ena Ray Banerjee*
Department of Zoology, Immunology and Regenerative Medicine Research Laboratory, University of Calcutta, Kolkata, West Bengal, India
*Corresponding Author : Ena Ray Banerjee
Department of Zoology, Immunology and Regenerative Medicine Research Laboratory
University of Calcutta, 35, Ballygunge Circular Road
Kolkata-700 019, West Bengal, India
Tel: +913324615445
E-mail: [email protected]
Received: October 07, 2016; Accepted: January 07, 2016; Published: January 14, 2016
Citation: Mitra S, Kar S, Surajlata K, Banerjee ER (2016) Screening of Novel Natural Product Derived Compounds for Drug Discovery in Inflammation. J Plant Biochem Physiol 3:159. doi:10.4172/2329-9029.1000159
Copyright: © 2016 Mitra S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Natural products are often a source for bioactive compounds which have great potential for developing novel therapeutic agents. The present study was to evaluate anti-inflammatory potential of six compounds A: Raffinose, B: Sucrose, C: Benzoic acid, D: Trehalose, E: Quinic Acid and F: Ferulic acid on bacterial lipopolysaccharide (LPS) induced inflammation in RAW 264.7 macrophages by employing in vitro methods: nitric oxide (NO) and Nitro blue tetrazolium (NBT) assays. These compounds are found in many plants, including palm, date palm, pomegranate, custard apple, wood apple, water chestnut and Indian plum, among others and it has been found that many of these compounds are effective anti-inflammatory agents, with anti-oxidant activities. The study revealed that compound C exhibited maximum anti-inflammatory activity at a concentration as low as one ng/ml. Compounds A, B and E also showed anti-inflammatory activity but at a higher concentration but compound D and F did not show antiinflammatory activity.

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