Seasonal Flu as a Triggering Factor for Acquired Thrombotic Thrombocytopenic Purpura
Adrien Joseph, Pascal Fangio, Christophe Barbier, Jan Hayon, Yann Loubières, Claire Pichereau, Hervé Outin, Mikael Alves*
Service of Medico-Surgical Intensive Care, Inter Communal Poissy Hospital, Poissy, France
- *Corresponding Author:
- Mikael Alves
Service of Medico-Surgical Intensive Care
Inter Communal Poissy Hospital
Saint-Germain-en-Laye, 10 rue du Champ Gaillard
78300 Poissy, France
E-mail: [email protected]
Rec date: March 31, 2016; Acc date: May 11, 2016; Pub date: May 18, 2016
Citation: Joseph A, Fangio P, Barbier C, Hayon J, Loubières Y, et al. (2016) Seasonal Flu as a Triggering Factor for Acquired Thrombotic Thrombocytopenic Purpura. J Hematol Thrombo Dis 4: 243. doi:10.4172/2329-8790.1000243
Copyright: © 2016 Joseph A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A 47 years old woman was admitted to our intensive care unit for acute asthma. An infection by influenza virus A was diagnosed and the patient presented during her hospitalization signs of thrombotic microangiopathy. Biologic analysis showed low A Desintegrin and Metalloproteinase with ThromboSpondin 1 - motifs - member 13 (ADAMTS13) activity and positive anti-A Desintegrin And Metalloproteinase with ThromboSpondin 1 - motifs - member 13 antibodies. Diagnosis of Acquired Thrombotic Thrombocytopenic Purpura was considered and a specific treatment was started with plasma exchange and intravenous administration of rituximab for relapse. Acquired Thrombotic Thrombocytopenic Purpura is considered an auto-immune disease. As such, it can be triggered by bacterial or viral infection. Many triggering factors have been described. Testing for influenza virus should be considered in epidemic situations when a Thrombotic Thrombocytopenic Purpura is diagnosed.