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ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Case Report

Sebaceous Cell Carcinoma: Wide Histological Spectrum and Correlation to Prognosis. A Case Report and Review of the Literature

Hussein A Morfeq1*, Alexandre N Odashiro2,4, Mohib W Morcos3, Patrícia R Pereira2,5, Bryan Arthurs6, Solange Milazzo7 and Miguel N. Burnier Jr2
1Department of Ophthalmology, King Abdulaziz University, Jeddah, Saudi Arabia
2Ocular Pathology Laboratory, McGill University, Montreal, QC Canada
3Department of Pathology, Université Laval, Québec, QC, Canada
4Department of Pathology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
5Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil
6Department of Ophthalmology, McGill University Health Centre, Montreal, QC, Canada
7Amiens-Picardie university Hospital, Amiens, France
Corresponding Author : Hussein Morfeq, MD
Ophtalmologie
Centre Hospitalier Universitaire Amiens-Picardie
Avenue René Laënnec-Salouel
80054 AMIENS Cedex
Saudi Arabia
Tel: +33651558966
E-mail: [email protected]
Received: October 05, 2015; Accepted: October 23, 2015; Published: October 27, 2015
Citation: Morfeq HA, Odashiro AN, Morcos MW, Pereira PR, Arthurs B, et al. (2015) Sebaceous Cell Carcinoma: Wide Histological Spectrum and Correlation to Prognosis. A Case Report and Review of the Literature. J Clin Exp Ophthalmol 6:486. doi:10.4172/2155-9570.1000486
Copyright: © 2015 Morfeq HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Sebaceous cell carcinoma (SCC) is the second most common eyelid malignancy among Caucasians, next to Basal cell carcinoma (BCC). It is an uncommon malignant neoplasm, and there are several reports describing the multiple clinical and histopathological presentations of SCC. Given its rarity, diagnosing SCC remains a challenge for ophthalmologists and pathologists, especially when conducting incisional biopsies. A 66-year-old male presented with a recurrent right upper eyelid mass for 4 years. The lesion recurred 4 times, and a biopsy was performed twice. In the first biopsy, a mild cell atypia was observed; the second biopsy was negative for atypia or cancerous cells. The patient was followed-up closely and in the 4th recurrence, a full thickness biopsy was performed. Histopathologically, areas of well-differentiated SCC were observed, as well areas of poorly differentiated SCC resembling BCC, squamous cell carcinoma in situ, and mucoepidermoid carcinoma. We highly recommend clinical and pathological suspicion of SCC in clinical cases of recurrent chalazion, treatment-resistant blepharoconjunctivitis, and undifferentiated malignant tumors of the eyelid present late in life.

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