alexa Secreted Protein Acidic and Rich in Cysteine (Sparc) in
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Secreted Protein Acidic and Rich in Cysteine (Sparc) in Cancer

Neveen Said1* and Dan Theodorescu2,3*
1Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA
2Departments of Surgery and Pharmacology, University of Colorado, USA
3University of Colorado Comprehensive Cancer Center, USA
Corresponding Authors : Neveen Said
Department of Radiation Oncology, University of Virginia School of Medicine
P.O. Box 800383, Charlottesville, VA 22908-0422, USA
Tel: 434-924-2393
Fax: 434-243-9789
E-mail: [email protected]
  Dan Theodorescu
Departments of Surgery and Pharmacology and Comprehensive Cancer Center
University of Colorado, Aurora, Colorado-80045, USA
Tel: 303-724-7135
Fax: 303-724-3162
E-mail: [email protected]
Received July 18, 2013; Accepted September 16, 2013; Published September 20, 2013
Citation: Said N, Theodorescu D (2013) Secreted Protein Acidic and Rich in Cysteine (Sparc) in Cancer. J Carcinogene Mutagene 4:151. doi: 10.4172/2157-2518.1000151
Copyright: © 2013 Said N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The local tissue microenvironment “niche” is composed of cellular and non-cellular components and plays an important role in regulating cell behaviour, during embryogenesis, and in physiologic and pathologic contexts including cancer. The cellular component is formed of specialized cell types endowed for the biological functions of the organ and tissues. The non-cellular component of the niche comprises the extracellular matrix (ECM) which functions not only as a scaffold for the cellular component maintaining tissue morphology, but dynamically influences fundamental aspects of cell behaviour. Matricellular proteins are a group of extracellular matrix (ECM) molecules that are not components of the structural scaffold of the ECM but serve as cell regulators and modulators of cellular behaviour and signaling. Secreted Protein Acidic and Rich in Cysteine (SPARC) is one of the matricellular proteins and is implicated in myriad physiological and pathological conditions characterized by extensive remodelling and plasticity. The role of SPARC in cancer is being increasingly recognized as it plays multi-faceted contextual roles depending on the cancer type, cell of origin and the surrounding milieu. The role of SPARC in the multistep cascades of carcinogenesis, cancer progression and metastasis has been studied retrospectively in human tumors, preclinical models using cell lines and models of oncogene-driven and carcinogen-induced cancers. Below we review several of these tumor types where SPARC biology has been evaluated.

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