alexa Selective Chromatid Segregation Mechanism Explains the Etiology of Chromosome 11 Translocation-Associated Psychotic Disorders: A Review | OMICS International
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Selective Chromatid Segregation Mechanism Explains the Etiology of Chromosome 11 Translocation-Associated Psychotic Disorders: A Review

Amar J. S. Klar*
Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Frederick, MD, USA.
Corresponding Author : Amar J.S. Klar
Gene Regulation and Chromosome Biology Laboratory
National Cancer Institute, Center for Cancer Research
National Institutes of Health
Frederick, MD 21702-1201, USA
Tel: + 301 846 5916
Fax: + 301 846 6911
E-mail: [email protected]
Received May 31, 2014; Accepted July 23, 2014; Published July 26, 2014
Citation: Klar AJS (2014) Selective Chromatid Segregation Mechanism Explains the Etiology of Chromosome 11 Translocation-Associated Psychotic Disorders: A Review . J Neurol Disord 2:173. doi: 10.4172/2329-6895.1000173
Copyright: © 2014 Klar AJS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The left and right hemispheres of the brain in most individuals are structurally and functionally specialized, but a significant minority displays an atypical variation in brain laterality specialization. Determining the biological basis of laterality specialization is essential for understanding the etiology of schizophrenia and bipolar disorder because they are often more prevalent in individuals with atypical brain laterality. These disorders are thought to be caused by contributions from hundreds of genes with small effects combined with environmental factors. However, lacking convincing evidence, the precise etiology of psychosis remains unknown. We have argued that chromosome 11 translocations associated with psychosis found in three families provide the only convincing evidence for the genetic etiology of psychosis. The paradoxes we try to resolve here concern the fact that the translocation breakpoints for chromosome 11 lie far apart, covering 40% length of the q arm, and the translocation associated psychoses is only 50% penetrant in each family. The selective chromatid segregation model has been proposed as a mechanism for the asymmetric cell division that initiates a cascade of gene regulation events in offspring cells to develop brain laterality in embryogenesis. The translocations we propose might cause random segregation of its sister chromatids to explain the result of 50% penetrance. We submit that errors in this system may explain the unique condition of these families. Here we review studies of model organisms that provide support to the model to explain brain laterality and psychosis development. We suggest that atypical brain laterality genetics predisposes carriers to develop general cases of psychoses due to developmental errors

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