alexa Senescent Sickle Erythrocytes and Endothelial Adhesion via Band 3 Peptides | OMICS International | Abstract
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Short Communication

Senescent Sickle Erythrocytes and Endothelial Adhesion via Band 3 Peptides

Kennedy JR*

Manatee Memorial Hospital, Bradenton Florida, FL, USA

*Corresponding Author:
Kennedy JR
Manatee Memorial Hospital
4704 Riverview Blvd
Bradenton FL 34209, USA
Tel: 941-746-1208
Fax: 941-792-285
E-mail: [email protected]

Received date: August 21, 2013; Accepted date: September 20, 2013; Published date: September 24, 2013

Citation: Kennedy JR (2013) Senescent Sickle Erythrocytes and Endothelial Adhesion via Band 3 Peptides. J Blood Disord Transfus 4:159. doi: 10.4172/2155-9864.1000159

Copyright: © 2013 Kennedy JR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The band 3 molecule is an anion channel for bicarbonate in the erythrocyte’s membrane that assumes a different role in senescent erythrocytes where it adopts a cluster configuration. These band 3 clusters expose previously hidden antigenic adhesive peptides which are recognized by natural band 3 antibodies that label their erythrocytes for reticuloendothelial elimination and prevent their endothelial adhesion. The sickle erythrocyte’s abnormal hemoglobin molecules cause them to experience premature senescence resulting in increased numbers of clusters, a portion of which remain uncloaked by antibodies and adhere to the vascular endothelium. The uncloaked clusters result from a deficiency of band 3 antibodies that are present in sickle cell anemia. The hypothesis presented is that the band 3 antibodies are insufficient in number to cloak all of the adhesive peptides present on cluster+ sickle erythrocytes and this is responsible for a portion of their adhesive pathology

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