Sensitive Quantitative Predictions of MHC Binding Peptides and Fragment Based Peptide Vaccines from Taenia crassiceps
Gomase VS* and Chitlange NR
Department of Bioinformatics, JJT University, Jhunjhunu Rajasthan, 333001, India
- *Corresponding Author:
- Dr. Gomase VS
Department of Bioinformatics
JJT University, Jhunjhunu Rajasthan, 333001, India
E-mail: [email protected]
Received Date: September 11, 2011; Accepted Date: March 29, 2012; Published Date: March 30, 2012
Citation: Gomase VS, Chitlange NR (2012) Sensitive Quantitative Predictions of MHC Binding Peptides and Fragment Based Peptide Vaccines from Taenia crassiceps. J Vaccines Vaccin 3:131. doi: 10.4172/2157-7560.1000131
Copyright: © 2012 Gomase VS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Taenia crassiceps is a member of the Taenia genus. It is a tapeworm. It is related to Taenia solium, the pork tapeworm, and to Taenia saginata, the beef tapeworm. Its larvae eat tiny holes in the human retina, eventually detaching it. The life cycle is when an adult lays eggs inside a wild canine. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Taenia crassiceps are important determinant for protection of host form parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 72 amino acids, which shows 64 nonamers. Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is important in vaccine development from Taenia crassiceps.