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Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA

Aneeka M Hancock1,3,Christopher C Lay1,3,4,Melissa F Davis1,3 and Ron D Frostig 1-4*
1Department of Neurobiology and Behavior, University of California, Irvine, California, USA
2Department of Biomedical Engineering, University of California, Irvine, California, USA
3The Center for the Neurobiology of Learning and Memory, University of California, Irvine, California, USA
4The Center for Hearing Research, University of California, Irvine, California, USA
Corresponding Author : Ron D Frostig
Professor, Department of Neurobiology & Behavior
2205 McGaugh Hall, University of California
Irvine, Irvine, CA 92697, USA
Tel: (949) 824-2883
Fax: (949) 824-2447
E-mail: [email protected]
Received August 28, 2013; Accepted September 30, 2013; Published October 05, 2013
Citation: Hancock AM, Lay CC, Davis MF, Frostig RD (2013) Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA. J Neurol Disord 1:135. doi: 10.4172/2329-6895.1000135
Copyright: © 2013 Hancock AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Previous research from our lab has shown that when using a rodent model of ischemic stroke (permanent middle cerebral artery occlusion), mild sensory stimulation, when delivered within two hours of ischemic onset, completely protects the cortex from impending ischemic stroke damage when assessed 24 hours post-occlusion. However, the long-term stability of this protection remains unclear. Using intrinsic signal optical imaging for assessment of cortical function, laser speckle imaging for assessment of blood flow, a battery of behavioral tests and cresyl violet for histological assessment, the present study examined whether this protection was long-lasting. When assessed 4 months post-occlusion (this length of time being equivalent to 10-15 years in humans), rats receiving sensory stimulation treatment immediately after ischemic onset exhibit normal neuronal and vascular function, and they are behaviorally and histologically equivalent to healthy controls (surgical shams). Thus, the complete neuroprotection due to cortical activation via sensory stimulation remains stable with time. These findings add support to the translational potential of this sensory stimulation-based treatment.


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