alexa Sentinel Lymph Node Biopsy in Papillary Thyroid Carcinoma
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Research Article

Sentinel Lymph Node Biopsy in Papillary Thyroid Carcinoma

Dan-Gui Yan, Bin Zhang*, Lin Liu, Li-Juan Niu, Chang-Ming An, Zheng-Jiang Li, Zhen-Gang Xu and Ping-Zhang Tang
Department of Head and Neck Surgery, Cancer Hospital& institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
Corresponding Author : Bin Zhang
Department of Head and Neck Surgery
Cancer Hospital & institute, Chinese Academy of Medical Sciences
Peking Union Medical College, No. 17 Panjiayuannanli
Chaoyang District, Beijing 100021, P.R. China
Tel: +86-10-87787190
Fax: +86-10-87787190
E-mail: [email protected]
Received November 28, 2013; Accepted December 07, 2013; Published December 09, 2013
Citation: Yan DG, Zhang B, Liu L, Niu LJ, An CM, et al. (2013) Sentinel Lymph Node Biopsy in Papillary Thyroid Carcinoma. Thyroid Disorders Ther 3:140. doi:10.4172/2167-7948.1000140
Copyright: © 2013 Yan DG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: The prognostic value of sentinel lymph node (SLN) biopsy mapping of tumor lymphatics for determining metastases in patients with papillary thyroid carcinoma (PTC) remains unconfirmed. Therefore, this study investigated the reliability and feasibility of the SLN biopsy to predict metastasis in PTC. Methods: Fifty-one PTC patients without clinical evidence of lymph node involvement (cN0) underwent preoperative lymphoscintigraphy with Technetium-99m-labeled dextran. Total or near-total thyroidectomy was performed with SLN biopsy guided by intraoperative injection of methylene blue dye and scanning with a hand-held gamma probe. All patients received selective neck dissections. Results: The SLN was identified by all three methods in all cases (100%). Identification rates for methylene blue dye and lymphoscintigraphy plus probe scanning were 90.2% and 96.1%, respectively. Metastases in SLNs were revealed in 31 and 38 cases by intraopertative frozen sectioning and final pathologic examination, respectively. Sensitivity, specificity, accuracy, and positive and negative predictive values of SLN biopsy were 97.4%, 100%, 98.0%, 100% and 92.3%, respectively. Conclusion: SLN biopsy in patients with cN0 PTC detected occult metastasis with high accuracy and may have the potential to select patients who require selective neck dissection.

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