Reach Us +3225889658
Separation of Mixtures of Chiral Compounds by their Distribution between Different Phases | OMICS International | Abstract
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Separation of Mixtures of Chiral Compounds by their Distribution between Different Phases

*Corresponding Author:

Copyright: © 0  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

To read the full article Peer-reviewed Article PDF image


Despite the dramatic development of enantioselective synthesis and chromatographic separation methods, optical resolution still remains the cheapest and operationally simplest method for producing pure enantiomers on a larger scale. The preparation of pure enantiomers due resolution is based on the formation of homo- and heterochiral supramolecular associations in the solutions of mixtures of chiral compounds. According to their selfdisproportionation (SDE) [1] these are distributed between phases. In this paper some methods are described, which were developed by our research group for the separation of enantiomeric and diastereomeric mixtures. The examples are mainly based on the long experience of our research group in the resolution of industrially important molecules. A presumable mechanism is also presented, which assume that the distribution follows the equilibrium of homo- and heterochiral double helical structures formed due the interactions.