alexa Septin Phosphorylation and Neuronal Degeneration; Role of Cyclin Dependent Kinase 5 (Cdk5) | OMICS International | Abstract
ISSN: 2168-975X

Brain Disorders & Therapy
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Special Issue Article

Septin Phosphorylation and Neuronal Degeneration; Role of Cyclin Dependent Kinase 5 (Cdk5)

Niranjana D Amin1, Philip Grant1, Yali Zheng2, Sashi Kesavapany3 and Harish C Pant1*
1Laboratory of Neuronal Cytoskeleton Protein Regulatory Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
2Departments of Nephrology, Ningxia People’s Hospital, Yinchuan, Ningxia 750021, China
3Neurobiology Program, Department of Biochemistry, Yong Loo Lin School of Medicine, 11 Medical Drive, Singapore 117597, Singapore
Corresponding Author : Harish C Pant
Laboratory of Neuronal Cytoskeleton
Protein Regulatory Section
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892, USA
E-mail: [email protected]
Received July 12, 2012; Accepted August 25, 2012; Published August 27, 2012
Citation: Amin ND, Grant P, Zheng Y, Kesavapany S, Pant HC (2012) Septin Phosphorylation and Neuronal Degeneration; Role of Cyclin Dependent Kinase 5 (Cdk5). Brain Disorders Ther S1:002. doi:
Copyright: © 2012 Amin ND, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

It is evident from the literature that most cellular functions are mediated by protein phosphorylation. It has also been demonstrated that abnormal phosphorylation of neuronal cytoskeletal proteins often leads to the pathology of several neurodegenerative diseases. For example, hyperphosphorylation of microtubule associated tau protein by Cdk5 and other kinases such as GSK3 has been linked to the formation of neurofibrillary tangles (NFTs) associated with Alzheimer’s disease (AD). Septins, a family of cytoskeletal proteins, also expressed in mammalian neurons, are involved in synaptic function and have also been linked to various neurological disorders. Although Sept5 phosphorylation by Cdk5 at the synapse has been reported to modulate exocytotic function, as yet, its phosphorylation has not been linked to hyperactivated Cdk5 as seen in AD. The present review begins with an overview of Cdk5 function in the nervous system, its role in neurodegeneration and its relationship to neuronal septins, their function and role in neurological disorders. In a summary speculation, we attempt to correlate synaptic function of Cdk5 phosphorylation of septins that may play a role in the etiology of neuronal disorders.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7