alexa Sequential Adjuvant Chemotherapy and Radiotherapy in Treatment of Early Stage Endometrial Carcinoma: Single Institutional Experience | OMICS International
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Research Article

Sequential Adjuvant Chemotherapy and Radiotherapy in Treatment of Early Stage Endometrial Carcinoma: Single Institutional Experience

Mutahir Tunio*, Mushabbab Al Asiri, Abdul Rehman Alhaddab, Yasser Bayoumi, Eyad Alsaeed, Abdel Salam Ismail, Khalid Riaz, AbdulAziz AlObaid and Abdullah Amro

Comprehensive Cancer Center, King Fahad Medical City (KFMC), Riyadh 59046, Saudi Arabia

*Corresponding Author:
Mutahir Tunio
MBBS, FCPS (Radiation Oncology)
Assistant Consultant, Radiation Oncology
Comprehensive Cancer Center
King Fahad Medical City (KFMC)
Riyadh 59046, Saudi Arabia
Tel: +966 1 2889999
Fax: 966 1 4614006
E-mail: [email protected]

Received date: June 14, 2012; Accepted date: June 23, 2012; Published date: June 25, 2012

Citation: Tunio M, Asiri MA, Alhaddab AR, Bayoumi Y, Alsaeed E, et al. (2012) Sequential Adjuvant Chemotherapy and Radiotherapy in Treatment of Early Stage Endometrial Carcinoma: Single Institutional Experience. J Nucl Med Radiat Ther S6:010. doi:10.4172/2155-9619.S6-010

Copyright: © 2012 Tunio M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Aim was to evaluate the additional benefit of adjuvant chemotherapy in patients of early stage endometrial carcinoma (EC) with adverse features.

Materials and methods: Between June 2006 and July 2011, 56 patients with EC after surgery were randomized to receive either adjuvant radiotherapy (RT) [35 patients] or adjuvant sequential chemotherapy and radiotherapy (CRT) [21 patients]. Median age was 57.6 years (40-80). Predominant stages were FIGO IB (44.6%) and IIA (26.7%). Mean body mass index was 35.9 kg/m2 (23-72).

Results: Median follow-up was 55 months (6-60). The Kaplan-Meier estimates for loco regional control (LRC), distant metastasis control (DMC) and overall survival (OS) for RT and CRT arms were; 85.7% vs. 74.2% (p 0.04), 85.7% vs. 85.7% (p 0.9) and 82.8% vs. 81% (p 0.8) respectively. Patients in CRT arm had earlier and higher pelvic recurrences {hazard ratios of 2.21 (1.45-7.85)}. Acute hematological grade3 toxicity was higher in CRT arm (9.5%) and no difference in acute or delayed non-hematological toxicities was seen between two arms.

Conclusion: Adjuvant chemotherapy in patients with EC after surgery is associated with inferior LRC and no additional benefit in DMC and OS. If adjuvant chemotherapy is considered it shall be given after adjuvant radiotherapy.

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