alexa Sequential Injection Analysis: A useful Analytical Tool
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Sequential Injection Analysis: A useful Analytical Tool in Drug Dissolution Testing

Paraskevas D. Tzanavaras*

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotelian University of Thessaloniki, GR-54124 Thessaloniki, Greece

*Corresponding Author:
Paraskevas D. Tzanavaras
Laboratory of Analytical Chemistry
Department of Chemistry, Aristotelian University of Thessaloniki
GR- 54124 Thessaloniki, Greece
Tel: 0030 2310997721
E-mail: [email protected]

Received Date: July 07, 2012; Accepted Date: July 09, 2012; Published Date: July 13, 2012

Citation: Tzanavaras PD (2012) Sequential Injection Analysis: A useful Analytical Tool in Drug Dissolution Testing. Pharmaceut Anal Acta 3:e114.doi: 10.4172/2153-2435.1000e114

Copyright: © 2012 Tzanavaras PD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Sequential-injection analysis (SI) is considered to be the second generation of flow injection techniques and was initially developed by Ruzicka and Marshall [1,2] as an alternative sample-handling technique to the well-established Flow injection analysis (FI) [3-5]. As can be seen in a typical SI setup in Figure 1, the heart of a SI manifold is a multiposition selection valve. Fluids are manipulated within the manifold by means of a bi-directional pump. A holding coil is placed between the pump and the common port of the multiposition selection valve. The selection ports of the valve are reservoirs, detectors, pumps, reactors, separators, special cells, other manifolds etc. After aspiration of a discrete volume (zone) of sample into the holding coil via the sample line, the sample can be subjected to very complex physical and chemical pre-treatment in different ways within the SI manifold. SI offers great potential for sample handling because it is a bidirectional, stopped-flow sample-handling technique enabling the sample to be serially processed in the different modules connected to the selection valve by means of repetitive aspiration and delivery steps. The advantages of SI over FI are the following: a) SI makes use of a simpler manifold that can be employed for a larger range of analytical methods without (or minimal) alterations in its physical configuration; b) in SI, discrete volumes of sample and reagents are aspirated and their consumption is drastically reduced; c) the bidirectional and stopped-flow operation of SI provides great scope for pre-treatment of the sample. This last attribute of SI makes it ideally suited to clinical and biochemical applications for which sample pre-treatment is usually necessary prior to the actual analytical measurement.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version