alexa Serial Comparison of Neointimal Coverage between Two Di
ISSN: 2329-9495

Angiology: Open Access
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Research Article

Serial Comparison of Neointimal Coverage between Two Different Concept Stents: Optical Coherence Tomographic Evaluation

Ryu Shutta1, Naotaka Okamoto1, Akihiro Tanaka1, Naoki Mori1, Masamichi Yano1, Nobuhiko Makino1, Yasuyuki Egami1, Yasushi Sakata2,Jun Tanouchi1 and Masami Nishino1*

1Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan.

2Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Corresponding Author:
Masami Nishino
Division of Cardiology
Osaka Rosai Hospital, 1179-3, Nagasone-cho
Kita-ku, Sakai-city, Osaka 591-8025, Japan
Tel: 81-72-252-3561
Fax: 81-72-250-5492
E-mail: [email protected]

Received Date: April 18, 2016; Accepted Date: May 20, 2016; Published Date: May 31, 2016

Citation: Shutta R, Okamoto N, Tanaka A, Mori N, Yano M, et al. (2016) Serial Comparison of Neointimal Coverage between Two Different Concept Stents: Optical Coherence Tomographic Evaluation. Angiol 4:175. doi:10.4172/2329-9495.1000175

Copyright: © 2016 Shutta R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Recently, two different concept drug-eluting stents including biolimus A9-eluting stents (BES) with biodegradablepolymer and everolimus-eluting stents (EES) with durable biocompatible-polymer are available. However, serial comparison of BES and EES on neointimal coverage is not fully investigated. We performed serial evaluation of neointimal coverage at 8 months (BES polymer remained) and 20 months follow-up (BES polymer absorbed) by optical coherence tomography (OCT) for 14 BESs and 10 EESs, and compared uncovered strut proportion (%Uncovered), malapposed strut proportion (%Malapposed) and average neointimal hyperplasia thickness (Ave- NHT), numbers of extra stent lumen (ESL) and multiple interstrut hollow (MIH) calculated by OCT between two DESs, at 8 months and 20 months follow-up, respectively. As a result. at 8 months, Ave-NHT of EES was significantly higher than BES (124 ± 65 É¥m vs 83 ± 47 É¥m, p<0.001) but %Uncovered and %Malapposed were similar between the two groups. At 20 months, %Uncovered and ESL of EES were significantly lower than BES (0.8 ± 5.7% vs 4.8 ± 12.7%, p<0.001 and 0.86 ± 1.28 vs 0.09 ± 0.16, p=0.043) and Ave-NHT of EES was significantly higher than BES (185 ± 88 É¥m vs 90 ± 46 É¥m, P<0.001). In conclusion, EES showed favorable neointimal healing compared to BES


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