alexa Series of 18 Cases of Clomiphene Resistant Anovulatory
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
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Case Report

Series of 18 Cases of Clomiphene Resistant Anovulatory Women with Polycystic Ovary Syndrome and Altered Response to FSH Stimulation

strong>Abha Majumdar* and Poonam Mishra

Centre of IVF and Human Reproduction, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India

*Corresponding Author:
Abha Majumdar
Centre of IVF and Human Reproduction
Sir Ganga Ram Hospital, Rajender Nagar
New Delhi, India
Tel: 01142251777
E-mail: [email protected]

Received date: November 09, 2016; Accepted date: December 13, 2016; Published date: December 20, 2016

Citation: Majumdar A, Mishra P (2016) Series of 18 Cases of Clomiphene Resistant Anovulatory Women with Polycystic Ovary Syndrome and Altered Response to FSH Stimulation.  J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol4:194. doi:10.4172/2375-4508.1000194

Copyright: © 2016 Majumdar A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The outcome of ovulation induction in anovulatory polycystic ovarian syndrome (PCOS) may depend, in part, on the pharmacologic compounds used, but also on individual patient characteristics, such as age, body mass index (BMI), hyper- androgenism, luteinizing hormone (LH), hyper-secretion, anti mullerian hormone (AMH) levels and possibly antral follicle count (AFC) with ovarian volume of these women. There exists a subset of clomiphene citrate (CC) resistant PCOS women who require stimulation of ovulation with high doses of human menopausal gonadotropin (hMG), after not having responded to chronic low dose step up regimes of recombinant follicle stimulating hormone (r-FSH).


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