SERPINE 1 Links Obesity and Diabetes: A Pilot Study
- *Corresponding Author:
- Dr. Alexzander Asea
Chief Division of Investigative Pathology
Scott & White Memorial Hospital and Clinic
and the Texas A&M Health Science Center
1901 South 1st street
Temple, TX 76504USA
Fax: +1-254-743- 0247
E-mail: [email protected], [email protected]
Received Date: May10, 2010; Accepted Date: June 16, 2010; Published Date: June 16, 2010
Citation: Kaur P, Reis MD, Couchman GR, Forjuoh SN, Greene JF Jr, et al. (2010) SERPINE 1 Links Obesity and Diabetes: A Pilot Study. J Proteomics Bioinform 3: 191-199. doi: 10.4172/jpb.1000139
Copyright: © 2010 Kaur P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the past decade there has been a dramatic increase in the number of Americans considered obese. Over this same period, the number of individuals diagnosed with diabetes has increased by over 40%. Interestingly, in a great number of cases individuals considered obese develop diabetes later on. Although a link between obesity and diabetes has been suggested, conclusive scientific evidence is thus far just beginning to emerge. The present pilot study is designed to identify a possible link between obesity and diabetes. The plasma proteome is a desirable biological sample due to their accessibility and representative complexity due, in part, to the wide dynamic range of protein concentrations, which lead to the discovery of new protein markers. Here we present the results for the specific depletion of 14 high-abundant proteins from the plasma samples of obese and diabetic patients. Comparative proteomic profiling of plasma from individuals with either diabetes or obesity and individuals with both obesity and diabetes revealed SERPINE 1 as a possible candidate protein of interest, which might be a link between obesity and diabetes.