Serum and Saliva Levels of High-Sensitivity C-reactive Protein in Acute Myocardial InfarctionMargrét Agnarsdóttir1*, Fredrik Ponten1, Hans Garmo2,3, Gunnar Wagenius4, Lorelei Mucci5, Kristina Magnusson1, Lars Holmberg2,3 and Sonja Eaker-Fält3
- *Corresponding Author:
- Iraj Mirzaii-Dizgah
Department of Physiology, School of Medicine
Aja University of Medical Sciences, Tehran, Iran
Tel/Fax: +98 21 88337921
E-mail: [email protected]
Received date: June 13, 2012; Accepted date: July 11, 2012; Published date: July 13, 2012
Citation: Mirzaii-Dizgah I, Riahi E, Miri R (2012) Serum and Saliva Levels of High- Sensitivity C-reactive Protein in Acute Myocardial Infarction. J Mol Biomark Diagn 2:128. doi: 10.4172/2155-9929.1000128
Copyright: © 2012 Mirzaii-Dizgah I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: The aim of this study was to evaluate the serum and saliva levels of high-sensitivity C-reactive protein (hs-CRP) in the patients with acute myocardial infarction (MI). Materials and Methods: In a cross sectional study, 28 patients with acute MI and 28 healthy subjects were recruited to the study, and hs-CRP levels which were measured in the serum, resting saliva, and stimulated saliva at the morning of first and second days of acute MI using ELISA method. Statistical analysis of the Student’s t test and Pearson correlation coefficient were used. Results: The mean stimulated saliva hs-CRP concentration (ng/ml) was significantly higher in the patients with acute MI at both the first and the second day of MI (2.08 ± 0.55 and 2.78 ± 0.75 respectively) than in the control group (0.26 ± 0.11). It was also higher in unstimulated saliva in the patients at the both days (3.75 ± 0.92 and 2.78 ± 0.75) than controls (0.68 ± 0.21). Serum hs-CRP level (μg/ml) was higher in the patients at the second day of MI (7.03 ± 0.36) compared to healthy individuals (3.84 ± 0.60). Furthermore, stimulated and unstimulated saliva hs-CRP levels correlated significantly with serum hs-CRP level (r = 0.249, P = 0.044; r = 0.289, P = 0.038 respectively). Conclusion: It can be concluded that saliva level of hs-CRP shows a massive rise after occurrence of acute MI, and salivary hs-CRP may serve as a point-of-care testing for detection of acute MI.