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Serum and Saliva Levels of High-Sensitivity C-reactive Protein in Acute Myocardial Infarction | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Serum and Saliva Levels of High-Sensitivity C-reactive Protein in Acute Myocardial Infarction

Margrét Agnarsdóttir1*, Fredrik Ponten1, Hans Garmo2,3, Gunnar Wagenius4, Lorelei Mucci5, Kristina Magnusson1, Lars Holmberg2,3 and Sonja Eaker-Fält3

1Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-75185 Uppsala, Sweden

2King’s College London, Medical School, Division of Cancer Studies, SE1 9RT London, UK

3Regional Cancer Centre, Uppsala University Hospital, SE-75185 Uppsala, Sweden

4Section of Oncology, Department of Oncology and Radiology, Uppsala University, SE-75185 Uppsala, Sweden

5Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston MA 02115, USA

*Corresponding Author:
Iraj Mirzaii-Dizgah
Department of Physiology, School of Medicine
Aja University of Medical Sciences, Tehran, Iran
Tel/Fax: +98 21 88337921
E-mail: [email protected]

Received date: June 13, 2012; Accepted date: July 11, 2012; Published date: July 13, 2012

Citation: Mirzaii-Dizgah I, Riahi E, Miri R (2012) Serum and Saliva Levels of High- Sensitivity C-reactive Protein in Acute Myocardial Infarction. J Mol Biomark Diagn 2:128. doi: 10.4172/2155-9929.1000128

Copyright: © 2012 Mirzaii-Dizgah I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: The aim of this study was to evaluate the serum and saliva levels of high-sensitivity C-reactive protein (hs-CRP) in the patients with acute myocardial infarction (MI). Materials and Methods: In a cross sectional study, 28 patients with acute MI and 28 healthy subjects were recruited to the study, and hs-CRP levels which were measured in the serum, resting saliva, and stimulated saliva at the morning of first and second days of acute MI using ELISA method. Statistical analysis of the Student’s t test and Pearson correlation coefficient were used. Results: The mean stimulated saliva hs-CRP concentration (ng/ml) was significantly higher in the patients with acute MI at both the first and the second day of MI (2.08 ± 0.55 and 2.78 ± 0.75 respectively) than in the control group (0.26 ± 0.11). It was also higher in unstimulated saliva in the patients at the both days (3.75 ± 0.92 and 2.78 ± 0.75) than controls (0.68 ± 0.21). Serum hs-CRP level (μg/ml) was higher in the patients at the second day of MI (7.03 ± 0.36) compared to healthy individuals (3.84 ± 0.60). Furthermore, stimulated and unstimulated saliva hs-CRP levels correlated significantly with serum hs-CRP level (r = 0.249, P = 0.044; r = 0.289, P = 0.038 respectively). Conclusion: It can be concluded that saliva level of hs-CRP shows a massive rise after occurrence of acute MI, and salivary hs-CRP may serve as a point-of-care testing for detection of acute MI.


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