Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during WithdrawalMauro Ceccanti1, Valentina Carito2, Mario Vitali1, Silvia Iannuzzi1, Luigi Tarani3, Sara De Nicolo’2, Marco Ceccanti1, Stefania Ciafre’4, Paola Tirassa2, Ida Capriglione1, Giovanna Coriale1, Angela Iannitelli5, George N. Chaldakov6 and Marco Fiore2,7*
- *Corresponding Author:
- Marco Fiore
Institute of Cell Biology and Neurobiology
IRCCS Fondazione Santa Lucia
Via del Fosso di Fiorano 64, 00143 Roma, Italy
Tel: +39 06 501-703-239
Fax: +39 06 501-703-313
E-mail: [email protected]
Received date: June 24, 2015; Accepted date: July 21, 2015; Published date: July 27, 2015
Citation: Ceccanti M, Carito V, Vitali M, Iannuzzi S, Tarani L, et al (2015) Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal. J Alcohol Drug Depend 3:214. doi: 10.4172/23296488.1000214
Copyright: © 2015 Ceccanti M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Many studies have suggested possible relationships between the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and alcohol addiction. Previous reports demonstrated severe changes in these neurotrophins in the serum of alcohol dependent patients and during withdrawal. Alcohol dependence syndromes during consumption and/or withdrawal are also characterized by elevated oxidative stress. Polyphenols, including olive polyphenols, are natural compounds known to possess marked antioxidant properties. Thus, this study was carried out in order to verify the effects of a blend of olive polyphenols supplementation containing mostly hydroxytyrosol (50 mg/day for 15 consecutive days) in alcoholic men during withdrawal on serum BDNF and NGF. As controls a group of alcohol dependent patients received sucrose tablets as placebo. BDNF and NGF were measured by ELISA on day 1, 3, 7 and 15 of the detoxification period. Some parameters of oxidative stress were analyzed too as free oxygen radicals defense (FORD) and free oxygen radicals test (FORT). No differences in oxidative status due to polyphenols were found. However, withdrawal elicited a mild increase in BDNF over two weeks that was counteracted on day 3 by polyphenols. As for NGF no effects of polyphenols supplementation were discovered to antagonize the expected NGF serum elevation during withdrawal. In conclusion the present data may indicate that monitoring serum BDNF and/or NGF in alcoholics undergoing detoxification could contribute to characterize alcohol dependence profiles to improve recovery processes throughout also antioxidant compounds.